November 9, 2025

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Potential to improve the burden of age-related macular degeneration: results from the Global Burden of Disease Study 2021

Potential to improve the burden of age-related macular degeneration: results from the Global Burden of Disease Study 2021

  • GBD 2019 Blindness and Vision Impairment Collaborators.Causes of blindness and vision impairment in 2020 and trends over 30 years, and prevalence of avoidable blindness in relation to VISION 2020: the Right to Sight: an analysis for the Global Burden of Disease Study. Lancet Glob health. 2021;9:e144–e160. https://doi.org/10.1016/s2214-109x(20)30489-7.

    Article 
    CAS 

    Google Scholar 

  • Taylor DJ, Hobby AE, Binns AM, Crabb DP. How does age-related macular degeneration affect real-world visual ability and quality of life? A systematic review. BMJ open. 2016;6:e011504. https://doi.org/10.1136/bmjopen-2016-011504.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Age-related macular degeneration: facts & figures, BrightFocus Foundation. 2019. Accessed 7 Mar 2025.

  • Zou M, Zhang Y, Chen A, Young CA, Li Y, Zheng D, et al. Variations and trends in global disease burden of age-related macular degeneration: 1990-2017. Acta Ophthalmol. 2021;99:e330–5. https://doi.org/10.1111/aos.14589.

    Article 
    PubMed 

    Google Scholar 

  • Xu X, Wu J, Yu X, Tang Y, Tang X, Shentu X. Regional differences in the global burden of age-related macular degeneration. BMC Public Health. 2020;20:410. https://doi.org/10.1186/s12889-020-8445-y.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Chakravarthy U, Wong TY, Fletcher A, Piault E, Evans C, Zlateva G, et al. Clinical risk factors for age-related macular degeneration: a systematic review and meta-analysis. BMC Ophthalmol. 2010;10. https://doi.org/10.1186/1471-2415-10-31.

  • Wang D, Jiang Y, He M, Scheetz J, Wang W. Disparities in the global burden of age-related macular degeneration: an analysis of trends from 1990 to 2015. Curr Eye Res. 2019;44:657–63. https://doi.org/10.1080/02713683.2019.1576907.

    Article 
    PubMed 

    Google Scholar 

  • Lin X, Lou L, Miao Q, Wang Y, Jin K, Shan P, et al. The pattern and gender disparity in global burden of age-related macular degeneration. Eur J Ophthalmol. 2021;31:1161–70. https://doi.org/10.1177/1120672120927256.

    Article 
    PubMed 

    Google Scholar 

  • GBD 2021 Diseases and Injuries Collaborators.Global incidence, prevalence, years lived with disability (YLDs), disability-adjusted life-years (DALYs), and healthy life expectancy (HALE) for 371 diseases and injuries in 204 countries and territories and 811 subnational locations, 1990-2021: a systematic analysis for the Global Burden of Disease Study 2021. Lancet. 2024;403:2133–61. https://doi.org/10.1016/s0140-6736(24)00757-8.

    Article 

    Google Scholar 

  • GBD 2021 Risk Factors Collaborators.Global burden and strength of evidence for 88 risk factors in 204 countries and 811 subnational locations, 1990-2021: a systematic analysis for the Global Burden of Disease Study 2021. Lancet (Lond, Engl). 2024;403:2162–203. https://doi.org/10.1016/s0140-6736(24)00933-4.

    Article 

    Google Scholar 

  • Xie Y, Bowe B, Mokdad AH, Xian H, Yan Y, Li T, et al. Analysis of the Global Burden of Disease study highlights the global, regional, and national trends of chronic kidney disease epidemiology from 1990 to 2016. Kidney Int. 2018;94:567–81. https://doi.org/10.1016/j.kint.2018.04.011.

    Article 
    PubMed 

    Google Scholar 

  • GBD 2017 Risk Factor Collaborators.Global, regional, and national comparative risk assessment of 84 behavioural, environmental and occupational, and metabolic risks or clusters of risks for 195 countries and territories, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017. Lancet (Lond, Engl). 2018;392:1923–94. https://doi.org/10.1016/s0140-6736(18)32225-6.

    Article 

    Google Scholar 

  • Wong WL, Su X, Li X, Cheung CM, Klein R, Cheng CY, et al. Global prevalence of age-related macular degeneration and disease burden projection for 2020 and 2040: a systematic review and meta-analysis. Lancet Glob health. 2014;2:e106–116. https://doi.org/10.1016/s2214-109x(13)70145-1.

    Article 
    PubMed 

    Google Scholar 

  • Yang X, Chen H, Zhang T, Yin X, Man J, He Q, et al. Global, regional, and national burden of blindness and vision loss due to common eye diseases along with its attributable risk factors from 1990 to 2019: a systematic analysis from the global burden of disease study 2019. Aging. 2021;13:19614–42. https://doi.org/10.18632/aging.203374.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Jiang B, Jiang C, Li J, Lu P. Trends and disparities in disease burden of age-related macular degeneration from 1990 to 2019: Results from the global burden of disease study 2019. Front public health. 2023;11:1138428. https://doi.org/10.3389/fpubh.2023.1138428.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • WHO. Ageing and health. https://www.who.int/news-room/fact-sheets/detail/ageing-and-health.

  • UN. Envision 2030: 17 goals to transform the world for persons with disabilities. Accessed 13 Apr 2022.

  • Kahloun R, Khairallah M, Resnikoff S, Cicinelli MV, Flaxman SR, Das A, et al. Prevalence and causes of vision loss in North Africa and Middle East in 2015: magnitude, temporal trends and projections. Br J Ophthalmol. 2019;103:863–70. https://doi.org/10.1136/bjophthalmol-2018-312068.

    Article 
    PubMed 

    Google Scholar 

  • Khairallah M, Kahloun R, Flaxman SR, Jonas JB, Keeffe J, Leasher J, et al. Prevalence and causes of vision loss in North Africa and the Middle East: 1990-2010. Br J Ophthalmol. 2014;98:605–11. https://doi.org/10.1136/bjophthalmol-2013-304068.

    Article 
    PubMed 

    Google Scholar 

  • Joachim N, Mitchell P, Burlutsky G, Kifley A, Wang JJ. The incidence and progression of age-related macular degeneration over 15 years: the blue mountains eye study. Ophthalmology. 2015;122:2482–9. https://doi.org/10.1016/j.ophtha.2015.08.002.

    Article 
    PubMed 

    Google Scholar 

  • Keenan TD, Agrón E, Domalpally A, Clemons TE, van Asten F, Wong WT, et al. Progression of geographic atrophy in age-related macular degeneration: AREDS2 report number 16. Ophthalmology. 2018;125:1913–28. https://doi.org/10.1016/j.ophtha.2018.05.028.

    Article 
    PubMed 

    Google Scholar 

  • Willeford KT, Rapp J. Smoking and age-related macular degeneration: biochemical mechanisms and patient support. Optom Vis Sci. 2012;89:1662–6. https://doi.org/10.1097/OPX.0b013e31826c5df2.

    Article 
    PubMed 

    Google Scholar 

  • Chung-Hall J, Craig L, Gravely S, Sansone N, Fong GT. Impact of the WHO FCTC over the first decade: a global evidence review prepared for the Impact Assessment Expert Group. Tob control. 2019;28:s119–28. https://doi.org/10.1136/tobaccocontrol-2018-054389.

    Article 
    PubMed 

    Google Scholar 

  • Flor LS, Reitsma MB, Gupta V, Ng M, Gakidou E. The effects of tobacco control policies on global smoking prevalence. Nat Med. 2021;27:239–43. https://doi.org/10.1038/s41591-020-01210-8.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Mehta MC, Narayanan R, Thomas Aretz H, Khanna R, Rao GN. The L V Prasad Eye Institute: a comprehensive case study of excellent and equitable eye care. Healthcare. 2020;8:100408. https://doi.org/10.1016/j.hjdsi.2019.100408.

    Article 
    PubMed 

    Google Scholar 

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